This study was carried out to estimate the toxic effect of lead acetate on hepatic and renal functions of rats , and the possible ameliorative effect of both vitamin C and E , and their combination with DMSA against lead intoxication . Thirty male albino rats were divided into five groups and administrated the following treatments for six weeks . group 1 received drinking water and served as control; group 2 received 100 ppm lead acetate; group 3 received 100 ppm lead acetate combined with 50 mg/kg b.wt of DMSA (ip) ; group 4 received 100 ppm lead acetate plus 160 mg/kg b.wt of vitamin C combined with 50 mg / kg b.wt of vitamin E; group 5 received in addition to lead acetate both vitamin C and E plus DMSA in the same previous dose . Lead acetate administrated induced a significant decrease in plasma alkaline phosphatase (ALP) , total proteins and plasma albumin , while it induced a significant increase in the plasma level of acid phosphatase (AP) , compared to the control. Significant elevation in the plasma level of urea , total lipids and triglycerides as a result of lead exposed were also observed , compared with control . DMSA , vitamin C combined with vitamin E , and DMSA combined with both vitamin C and E induced a significant elevation in the plasma level of ALP , total proteins and albumin respectively , whereas a significant decrease in the plasma level of AP , urea , total lipids and triglycerides , respectively were observed . Thus , lead acetate induced toxic effect in hepatorenal functions , whereas , administration of DMSA ,vitamin C plus E and also DMSA combined with both vitamins C and E could ameliorate the toxic effect of lead acetate on the kidney function and to somewhat on the liver function .