Substituted hydrazones have been used extensively in organic synthesis. The active centers of a hydrazone are the carbon and nitrogen atoms which are mainly responsible for their physical and chemical properties. due to their reactivity toward electrophiles and nucleophiles, hydrazones are used for the synthesis of heterocyclic compounds having a variety of biological activities. Hydrazones and their derivatives are known to exhibit a wide range of biological activities such as anti-oxidant, anti-inflammatory, anti-convulsant, analgesic, anti-microbial, anti-cancer, anti-protozoal, antiparasitic, anti-platelet, cardio-protective, anti-helminthic, anti-diabetic, anti-tubercular, anti-HIV, and so forth. In recent years, there have been considerable developments in this field and many new aspects of hydrazone chemistry and many applications have evolved.