The West Assiut Power Plant is a cornerstone of the development projects in Upper Egypt. The first stage of this project was opened in May 2016, covering an area of approximately 85 acres, boasting a capacity of 1,500 MW of electricity, and entailing an initial cost of $1.5 billion. However, the realization of its full potential hinges on the availability of sustainable water resources, which is essential for continued growth and prosperity in Upper Egypt. The main objective of the this study is providing a comprehensive detection and evaluation of groundwater-bearing aquifers in West Assiut governorate, as well as understanding the interconnection and interactions among these aquifers. Additionally, an exhaustive qualitative assessment of groundwater suitability for various purposes ranging from drinking and domestic use to livestock husbandry and agricultural irrigation is performed. The study detected the properties of the aquifers including transmissivity, storage coefficient, etc. through a detailed analysis of 46 wells to facilitate the required water resources to sustain the development and prosperity of Upper Egypt. The hydrochemical analysis of groundwater samples were detected to determine the hydrochemical properties of the groundwater. The TDS value is varied from 643 mg/l (fresh water) to 5715 mg/l (Moderately saline water)