Background: Internationally recognized medical schools assign great efforts towards introducing Leadership courses for their undergraduates. The impact of such courses is usually associated with positive outcomes. Objective: This study aimed to assess the impact of a newly launched leadership and management course on fourth-year medical students at Ain Shams University on their knowledge, attitude, and satisfaction. Methods: one arm intervention trial was conducted on 410 students who completed the course and its final exam.  Pre and post-tests were used to assess students' leadership knowledge and attitude. A satisfaction survey was delivered at the end of the course.  All material was delivered to students through their E-learning Moodle platform. Students' exam results were analyzed as an indicator of students' achievement. Results: 102 students responded to pre and post-tests and satisfaction surveys.  There was a significant improvement in their knowledge and attitude after attending the course. Eighty-nine of them (87.3%) highly rated the course as “excellent - very good". Eighty students (78.4%) agreed that the course was well organized. Seventy-seven students (75.5%) appreciated the course structure and content. Students appraised their professors' performances, teaching ways, course design, and coordination. Some students suggested the introduction of face-to-face sessions for discussions and role-play.  Students' success percentage in the final exam was 92.4%. Conclusion: Students' knowledge and attitude were improved and were satisfied with various aspects in the course.