Background: Hyperbaric Oxygen Therapy holds significant importance in the realm of medical treatments. It serves as an adjunctive therapy in conditions such as diabetic foot ulcers. Aim of the study: To assess nurses' awareness regarding hyperbaric oxygen therapy among patients with diabetic foot ulcer. Research design: A descriptive research design was used in this study. Setting: This study was conducted in hyperbaric oxygen therapy unit of Kobry El-kobba hospital. Sample: All nurses working in hyperbaric oxygen therapy unit included 70 nurses. Tools: Two tools were used: 1st tool was structured Interviewing questionnaire. Consisted of 3parts: Demographic characteristics, knowledge assessment , and nurse's attitude regarding hyperbaric oxygen therapy. 2nd tool was observational checklist regarding hyperbaric oxygen therapy among patients with diabetic foot ulcer. Results: 65.7% of nurses had poor level of knowledge 74.3% of nurses had adequate level of practice regarding hyperbaric oxygen therapy among patients with diabetic foot ulcer, 75.7% of nurses had positive attitude regarding hyperbaric oxygen therapy among patients with diabetic foot ulcer, and there was highly statistically significant relationship between nurses total knowledge, total practices and total attitude with (P= 0.000). Conclusion:one third of nurses had a good level knowledge regarding Hyperbaric Oxygen Therapy among patients with diabetic foot ulcers , more than quarter of nurses had inadequate level of practice, and less than quarter of nurses had negative attitude . There was highly significant positive correlation between nurses' knowledge, practices and their attitude. Recommendation: Providing training programs for nurses to increase their level of skills .