Background:The study of smart leadership is one of the important topics in the health sector, which has a role in achieving organizational prosperity and promoting the employment of smart leadership for senior management in applying the most appropriate practices and decisions to achieve prosperity in the sector healthy. Aim of the study: This study aims to assess relationship between smart leadership and organizational prosperity. Research Design: A descriptive correlational research design was utilized to conduct the study. Setting:The current study was conducted at Military Production Hospital in Helwan . Subjects: The study subjects was include all nurses available and willing to participate at the study during data collection. Tools of Data Collection: two tool was used for data collection included; Smart leadership questionnair,oranizational prosperity questionnair. Results: The study results revealed that more than half of the studied nurses have a perceived a moderate level of smart leadership and organizational prosperity as a perceived by studied nurses. In addition to the presence of a highly statistically significant difference between levels of smart leadership and organizational prosperity, at P = 0.000. Conclusion:This study concluded that represents that there was a highly statistically significant positive strong correlation between smart leadership and organizational prosperity as perceived by the studied nurses. Recommendations: This study recommended that perform training program to enhance perception of the staff toward smart leadership and organizational prosperity, Provide complementary human relations between staff nurses and leaders.