Background: Polycystic Ovary Syndrome (PCOS) is a hormonal disorder common among females of reproductive age. The most clinical symptoms are irregular periods infrequent, irregular or prolonged menstrual cycles, excess facial and body hair, and occasionally severe acne. Aim: This study aimed to assess awareness of females regarding polycystic ovarian syndrome at health insurance hospital in Minya governorate. Study design: Descriptive research design was used in this study. Sample: Purposive sample include 100 females with polycystic ovary syndrome. Setting: It was conducted at obstetric & gynecological outpatient clinics at the health insurance hospital in Minya governorate. Tools: One tool included four parts: 1st: Demographic characteristics of female, 2nd: Medical history of female, 3rd: Females' knowledge, 4th: Females' reported practices and 5th : Females' attitude about polycystic ovary syndrome. Results: 42 % of the studied females had poor knowledge, 33 % of the studied females had unsatisfactory reported practices, and 52 % of the studied females had negative attitude. Conclusion: Less than half of the studied females had poor total knowledge, most of them had unsatisfactory total reported practice and more than half of the studied females had negative attitude. There a relation between females' knowledge, and reported practices towards studied females regarding polycystic ovary syndrome. There is statistically significant relation between studied females' demographic data and their knowledge, reported practices and attitude for studied females regarding polycystic ovary syndrome. Recommendations: Design health education program for females about females' knowledge reported practices and attitude which include all information about polycystic ovary syndrome.