Background: Human papillomavirus (HPV) is the commonest viral sexually transmitted infection
in the world and the leading cause of cervical cancer. Aim: To evaluate the effect of educational
guidelines on late adolescent females knowledge and attitude regarding human papilloma virus. Research
Design: A quasi-experimental research design was used to achieve the aim of the study. Setting: The
study was conducted at Faculty of nursing Alazhar University ,Cairo, Egypt.. Sample:. A convenience
sample was used to recruit 120 nursing student. Tools: three tools were used; Tool(I): structured
interviewing questionnaire consists of three part Part I: General characteristics Part II :Health History.
Part III: Knowledge assessment questioner , Tool(II): Attitude of Females student's towards human
papilloma virus. Tool III: Student's Satisfaction tool. Results: The finding of this study showed that the
mean age of studied sample 20.27±0.444 years. There was improvement with highly statistically
significant difference observed in students' knowledge and attitude regarding HPV infection and its
vaccination at post-intervention phase compared with pre-intervention phase (p < /p>