Background: Psychological hardiness and social support are two necessary health-elevating factors that strengthen patients to remain both psychologically and physically health despite encountering negative life events. A Psychiatric nurse plays a crucial role in providing psychological care and support for cardiac patients. The Aim: of This study was to assess psychological hardiness and social support among patients with cardiac diseases. Design: A descriptive research design. Setting: The study was conducted at Ain Shams University Hospital in Cairo. Subject: A Convenient sample of (324) patients were included in this study. Data Collection tools: Tool (I) Socio demographic and medical sheet (II) Psychological hardiness questionnaire & (III) Social Support scale. Results: the study results revealed that 44.8% of the studied patients were high level of psychological hardiness. while that 64.8% of the studied patients were high level of their family support. Conclusion: the main result showed about half of the studied patients have high level commitment and control of psychological hardiness, while more than one third have high level challenge of psychological hardiness, while less than one quarter have low level commitment and control of psychological hardiness and one quarter have low level challenge of psychological hardiness. In addition, there was a statistically significant highly a positive correlation between total score of psychological hardiness and total of social support of the studied patients Recommendation: less educated not worked and poor cardiac patients must be considerate as nursing priority target group for educational and counseling program.