Background: Psoriasis represents one of the most common autoimmune skin diseases worldwide, causes high burden and impacts on patients' quality of life. Aim of the study: To assess awareness of undergraduate nursing students regarding psoriasis disease at the British University in Egypt. Research design: A descriptive design was utilized in this study. Setting: The study was conducted at faculty of nursing- the British University in Egypt. Sample: A convenience sample of 520 nursing students from different study years. Tools: A structured questionnaire includes 3 main parts: Demographic characteristics, nursing students' knowledge, and nursing students' attitude toward psoriasis disease. Results: 6% of the studied sample had good total knowledge and 16.3% had fair total knowledge, while 77.7 % had poor total knowledge regarding psoriasis disease. Also, 29.4% had positive attitude and 70.6% had negative attitude toward psoriasis disease. Conclusion: More than three-quarters of the studied nursing students had poor total knowledge regarding psoriasis disease, while higher than two-thirds of them had a negative attitude toward psoriasis. Additionally, there was a highly statistically significant relation between total knowledge and total attitude among the studied nursing students. Recommendations: Educational program and sessions should be conducted by academics for nursing students in order to improve their knowledge and attitude toward psoriasis.