Background: Short stature is a chronic health condition. the better adaption of the condition to the family's everyday life, the less burdensome the disease is perceived and classified by the affected family member. The personal responsibility of those involved is fundamental and directly influences the medical prognosis. Aim: To assess biopsychosocial burden and adjustment of families of children with short stature. Design: descriptive research design will be used. Setting: This study was conducted at health insurance outpatient clinics for students at El sharkia and El Qalubia government. Sample: A purposive sampling will be used to choose (196) families. Tool. A structured Interviewing questionnaire which divided to Five part were used for data collection. 1stpart: used to assess demographic data of primary school students and parent.2ndpart: present and past history for child and family.3rdpart: Family knowledge about short stature. 4thpart: Biopsychosocial burden of family of children with short stature. 5thpart: Adjustment of family of children with short stature. Result: The study result revealed that 66.8% have a good knowledge with total burden mean± SD 101.4133 ± 61.92334, and 63.3% had a good adjustment, highly significant Correlation between Total Scores of Knowledge, Total Scores of Burdens with r=0.867 and p value =0.000 and Total Score Adjustment of the Studied Sample regarding Short Stature with r=0.984 and p value=0.000. Conclusion: There were highly significant relation between Total Knowledge score, Total burden, Total adjustment score levels and studied Sample socio-demographic data except some. Recommendations: health awareness program for families regarding short stature.