Background: Nursing students encounter occupational risks during part time working.Work of nursing students during study may effect on academic performance. Aim of this study: This study aimed to assess the effect of work during study on academic performance and health hazards among nursing students at Helwan University. Design: A descriptive research design was utilized to achieve the aim of this study. Setting: the study was conducted at Faculty of Nursing – Helwan University. Sample: A convenient sample of 299 for nursing students from second, third & fourth grades. Tools: Two tools were used in this study: Tool I: A Structured interviewing questionnaire which composed of; sociodemographic characteristics of nursing students, work field information and nursing students' knowledge about health hazards at work place. Tool II: Academic performance assessment. Results: demonstrates that, 57.9% of studied nursing students had good knowledge about health hazards, and29.1% of them had poor knowledge about health hazards at workplace. Moreover, 67.6% of the studied nursing students had a satisfaction academic performance, While, 32.4% of them had a unsatisfaction in total academic performance. Conclusion: there was statistically significant positive correlation between total knowledge level and total academic performance level regarding to health hazards during working. Recommendations: Develop and implement an educational program to increase nursing student awareness about health hazards at workplace.