The COVID-19 and its variants outbreak proved to be one of the most transformative events in the modern period. Aim: The aim was to assess awareness regarding COVID-19 and its variants among preparatory school students. Design: A descriptive research design was used. Setting: This study was conducted at three preparatory schools were selected randomly in El-Masara, Helwan, Egypt. Sample: A multistage random sample of 210 students from 1st and 2nd preparatory grades. Tool: One tool was used a self-administered questionnaire sheet consists of five parts; students' demographic data, medical health history and COVID-19 related experiences, knowledge, attitudes and reported practices regarding COVID-19 and its variants. Results: 60.5% of the studied students had poor knowledge about COVID-19 and its variants, 61.4% of them had negative attitudes toward COVID-19 and its variants, and 72.4% of them had unsatisfactory level of reported practices regarding COVID-19 and its variants Conclusion: more than three-fifths of the studied preparatory school students had poor knowledge and had negative attitudes toward COVID-19 and its variants, and less than three-quarters of them had unsatisfactory level of reported practices regarding COVID-19 and its variant. Also, there was a highly statistical significant positive correlation between students' total level of knowledge, attitudes & reported practices regarding COVID-19 and its variants (P < 0.001). Recommendations: Design and implement awareness programs for all preparatory school students to raise their awareness regarding COVID-19 & its variants