Background: As the coronavirus disease, 2019 (COVID‐19) pandemic is considered the largest community health event in more than a century, the significance of nursing is being perceived by legislators and communities. Aim: The study aimed to assess nurse managers' role to overcome challenges facing them during COVID-19 pandemic. Methods: Descriptive design was used. Tools: Two tools were used to collect data, nurse managers' knowledge about COVID-19 pandemic, and role of nurse managers during COVID-19 questionnaire. Result: there were less than three quarters (72.5%) of nurse managers had high total level of challenges during COVID-19 pandemic. As well, more than half (52.5%) of studied nurse managers performed their role facing COVID-19 challenges with a high level, while more than quarter of them (27.5%) had moderate level and only one fifth (20%) of studied nurse managers performed their role facing COVID-19 challenges with a low level. Conclusion: the study finding concluded that less than two thirds of the studied nurse managers had high level of knowledge about COVID-19. Also, the study show that the highest level of challenges during COVID-19 pandemic facing the nurse managers were stigma and discrimination challenges. Furthermore, the study illustrated that nurse managers' role were to improve coworkers' relations, increase community awareness and knowledge about COVID-19 pandemic, and the necessity of healthcare providers' role. Recommendations: Healthcare organization should develop training program conferences and seminars for nurse managers about crisis management including COVID-19 pandemic. Further studies: Assess the long-term impact of the pandemic on the nursing profession.