Background: External Fixation is an effective treatment modality for complex fractures without increasing soft tissue damage. Patients with external fixator have limited ability to perform activities of daily living and self-care practices. Aim of the study was to evaluate the effect of an educational program on self-care practice for patients with external skeletal fixation. Design: A quasi-experimental research design was used. Setting: The study was carried out at the orthopedic department and orthopedic outpatient clinics at Nasser Institute for Research and Treatment. Subjects: A purposive sample of (90) adult patients from both genders with external skeletal fixation. Tools: Three tools were used in the study included: Patients' structured interview questionnaire, patients' self-care practices checklist and Barthel Index for patients' activities of daily living. Result: There was a highly statistically significant relation regarding total patients' knowledge between pre, post and follow-up (after one month) of the educational program implementation, there was a significant improvement in all patients' self-care practices towards external skeletal fixation and Barthel index for patients' activities of daily living with a highly statistically significant difference. Conclusion: There was a highly statistically significant correlation between total patients' knowledge, total patients' self-care practices and total Barthel Index score for patients' activities of daily living at pre, post and follow-up (after one month) implementation of the educational program. Recommendations: The educational intervention and patient's psychosocial support should be included in the routine nursing care