Background: Virtual team leadership plays a significant role in the nursing profession, especially in today's technologically advanced healthcare landscape. With the increasing adoption of telemedicine and digital health platforms, nurses are frequently collaborating and working together in virtual teams Aim of the study: To assess the perception of nursing personnel about virtual team leadership. Research Design: A descriptive research design was used to conduct this study. Setting: The study was conducted at um Al-Masryeen Hospital located in Giza District, Giza Governorate. Subjects: A convenience sample of all avaliable nursing personnel (100) working at the previously mentioned setting. Tools of Data Collection: One tool was used for data collection included; virtual team leadership scale. Results: The study results revealed that more than four-fifths (88%) of studied nurses have a higher perception about virtual team leadership. But they have the highest perception percentage (93%) about interactivity dimension with a total x̅ + SD= 26.38 + 3.20 and the lowest perception percentage (69%) about human relations with a total x̅ + SD= 24.57 + 3.73 Conclusion: Almost of studied nurses had high level of perception about virtual team leadership. And with a highly statistically significant difference p=0.000** Recommendations: Provide resources for establishing virtual environments such as digital communication tools in supporting nursing personnel, train nursing personnel about how to deal with advanced technology and virtuality and implement remote work outside traditional offices.