Background: The COVID-19 pandemic has had far-reaching effects on various aspects of human life, including health and well-being. The effect of the covid 19 pandemic on the female reproductive cycle. Aim: This study aimed to study the effect of covid19 pandemic on female reproductive cycle. Methods: A descriptive design was used to accomplish this study, which was carried out on 90 female patients at Homyate Tanta Hospital. Two tools were used in this study and classified as the following structured interviewing questionnaire, health assessment sheet. Results: most of the studied females have good pattern of reproductive system before and after Quarantine, respectively. While nearly two thirds of them have poor pattern during Quarantine. In addition, most of them have good total pattern Conclusion: Slightly more than three quarters of the studied hospitalized females had good level of total knowledge about Covid-19 preventive measures. As well, most of the studied hospitalized females had good pattern of reproductive system before and after Quarantine. While nearly two thirds of them had poor pattern during Quarantine. In addition, most of the studied females had average stress during Quarantine, nearly two thirds of them had low stress after Quarantine, and more than three quarters of them had average total stress levels. Recommendations: Educate females about the possible influence of environmental stress on their physiology, as well as ensure nurses are fully aware of the reasons why menstrual cycle changes may arise.