Background: Physical impairment is a disability that limits a student's physical capacity to move, coordinate actions or performs physical activities. It is accompanied by difficulties in one or more of the following areas: physical and motor tasks, independent movement, and performing daily living functions. Aim: This study aimed to assess the student s' knowledge and practice regarding physical impairments at Helwan University. Research hypothesis: Descriptive research design was used in this study. Sample: Purposive sample include 118 students, who suffering from physical impairment. Setting: Excellence center for students with disabilities, three faculties (College of Commerce, college of literature, and the college of law), and emergency clinics at Helwan University. Tools for data collection: One tool included four parts, 1st: Interview questionnaire include socio-demographic characteristic, 2nd: Past and present history of student with physical impairments, 3rd: Students' knowledge of student with physical impairments, 4th: Students reported practice. Results: 80 % of studied subjects had good total knowledge about physical impairments. While 15 % of them had fair total knowledge about physical impairments. While 5 % of studied subjects had poor total knowledge about physical impairments, 63.6 % of the studied subjects had insufficient reported practices about physical impairments and that insufficient reported practices were improved about physical impairments where, it became only 1.7 %, the percentage of the studied subjects who had sufficient reported practices were became 98.3%. Conclusion: The current study concludes that the most of studied sample had unsatisfactory level of knowledge and pr