Background: Assertiveness is significant communication style that is essential skills for nurse students. Having assertiveness skills and high self-esteem is crucial for nursing students to ensure competent and safe practice. In addition, having excellent communication skills is necessary for nurse students before starting their carrier. Aim of the study: this study aimed to assess assertiveness, self-esteem and communication skills among nursing students of Helwan University. Design: A descriptive design used in this study. Setting: This study carried out at the psychiatric and mental health nursing classes, Faculty of Nursing - Helwan University. Sample: A convenience sample of (104) university nursing students were included for the conduction of this study. Tools of data collection: The study tools divided into four tools. I: Socio-demographic Sheet. II: Rathus Assertiveness Scale. III: Rosenberg Self Esteem Scale and IV: Communication Skills Scale. Results: the present study show that the total score of nursing students regarding to assertiveness was low, more than three quarter of nurse students were unassertive. Regarding to self-esteem level only around ten percent of nursing students had high level of self-esteem, while the majority of nursing students had low level of self-esteem. In addition, most of nursing students had low level of communication skills. Ninety percent of students showed low communication skills Recommendation: Incorporating training program to improve level of assertiveness, self-esteem and communication skills as an eligible training course of the undergraduate nursing program.