Background: Coronavirus disease is an emerging respiratory disease that is caused by a novel coronavirus and has shown a fatal impact on pregnant women and fetuses. Aim: the current study aimed to assess pregnant women's knowledge and practices regarding preventive measures against coronavirus. Design: a descriptive design was used to achieve the aim of the study. Setting: the study was conducted at outpatient antenatal clinic in Helwan general hospital in Cairo, Egypt. Sample: Purposive sampling was utilized in the present study to recruit 89 pregnant women. Tools: three tools for data collection. First, a structured interviewing questionnaire is used to assess the pregnant women's demographic characteristics as well as their obstetric history. Second Tool: assess the level of pregnant women's knowledge regarding preventive measures against the coronavirus. Third Tool: Assess pregnant women's practices regarding preventive measures against the coronavirus. Results: the results revealed that there was a highly statistically significant relationship between total pregnant women's knowledge, educational level, and whether they had previously been diagnosed with coronavirus before pregnancy. Conclusion: The study was concluded that nearby half of pregnant women had unsatisfactory knowledge toward coronavirus preventive measures and more than half of pregnant women had inadequate practice toward coronavirus preventive measures. Recommendations: Pregnant women should be educated about coronavirus prevention measures.