To evaluate the expression of drought tolerance for bread wheat, six parents diverse in their response to drought i.e., Giza 171 (P1), Sakha 95 (P2), Bohouth 6 (P3), Cham 8 (P4), Gemmiza 12 (P5) and Masr 3 (P6) and their 15 F₁ crosses at 100% water requirements, and 70% water requirements sown in randomized complete blocks design season 2023/24 to estimate some genetic parameters for day to heading, days to maturity, chlorophyll pigments, superoxide dismutase activity, the activity of ascorbate peroxidase, proline content, number of spikes/plant, number of grains/spike, 100-kernel weight, and grain yield/plant. slightly significant differences were shown for most studied traits across all water regimes. The ratios of general combining ability to specific combining ability exceeded one for the examined traits, with some exceptions, signifying the influence of additive gene effects on the inheritance. The parental genotypes as good combiners, for earliness were P1 under both treatments, as well as P1, P2, and P3 at 70% water requirements, for physiologic and agronomic traits. The crosses P3 × P4 and P4 × P6 were the best combinations across the two treatments depending on physiological response and yield attributes. Most hybrids had significant heterotic values for agronomic and bio-physiological traits. The genotypic and phenotypic coefficients of variation varied from 1.71% for days to maturity to 14.83% for proline content, and from 1.90% for days to maturity to 16.64% for the activity of ascorbate peroxidase under well-watered, respectively; likewise, from 2.03% and 1.80% for days to maturity to 14.69% and 14.05% for chlorophyll a, respectively under water deficit.