The most dangerous biotic-stress impact in confronting the common bean was damping-off disease. This study aims to examine eco-friendly means instead of using traditional chemical fungicides. Pre-sowing seeds treatment with gradual doses of gamma irradiation (0, 20, 40, 60, 80, and 100 Gy) was chosen compared to Vitavax fungicide. Two germination tests and two open field experiments were conducted during summer seasons of 2021 and 2022 using common bean "Giza-7". Generally, all the treatments were affected significantly all of the studied characters, in both seasons. In particular, the treatments of 20 Gy or Vitavax were significantly enhancing the vigor of common bean plants in confronting the biotic stress of damping-off disease. They, significantly, increased the germination%, survival%, plant height, shoot fresh and dry weights, chlorophyll reading, 100-seed weight, seed yield fad^-1, seeds content of N, P, and K%, seeds crude protein, enzymes activity of CAT, POD, and PPO, leaves total phenols and total soluble proteins without significant difference between them. While, the same two previous treatments shared their ability to significantly reduce pre-, post-, and total damping-off percentages, in both seasons. Concerning the cluster analysis of total soluble proteins, the results revealed that the closest treatments were 20 Gy and Vitavax. This study's findings suggest the capability of replacing the fungicide Vitavax with a low dose of gamma irradiation (20 Gy) as pre-sowing seeds treatment for enhancing the physiological status of common bean plants in addition to disease aspects when grown under the biotic stress of damping-off disease.  gamma irradiation, biotic stress, damping-off disease, enzymes activity.