Current study was conducted to evaluate the effect of applied anhydrous ammonia (AA) and compost (C) on the growth, yield and grain nutritional status of wheat crop. Therefore, a factorial experiment including 6 treatments (3 anhydrous ammonia rates x 2 levels of compost amendment) with 3 replications was conducted at Tamiya farm affiliated to the Agricultural Research Center in Fayoum Governorate during the seasons 2016/2017 and 2017/2018. Anhydrous ammonia was injected directly into the soil at rates of (control (50), 70, 90) kg N fed^-1, however compost amendment was added at levels of (control (zero addition) and 5) t fed^-1. The results showed that the highest values of dray matter accumulation rate, grain nutritional status, straw yield and grain yield of wheat crop were associated with the addition of AA at a rate of 90 kg N fed^-1 in combination with 5 t fed^-1 of compost amendment. Interestingly the use of AA at the rate of 90 kg N fed^-1 didn't cause significant effect on above-mentioned parameters as compared with AA at the rate of 70 kg N fed^-1.  Accordingly it could concluded that the use of 70 kg N fed^-1 instead of 90 kg N fed^-1 coupled with compost amendment could be applied as a valuable a gro-management and environment-friendly approach for enhancing growth and yield of wheat crop, improving soil quality and increasing fertilization use efficiency under the conditions of Fayoum Governorate-Egypt.