Two field trials were carried out in Fayoum Governorate (Tamiea, Station of Agricultural Research), Egypt, during the seasons (2019/20) and (2020/21). This study aims at determining the response of yield components grain and straw yields and some water relations of barley variety (Giza 132) to different rates of available soil moisture depletion and nitrogen fertilization forms. Three irrigating regimes at 40%, 60%, and 80% of total available soil moisture depletion (ASMD) and three N fertilization forms, i.e., ammonium sulfate (20.5%N), ammonium nitrate (33.5%N), and Urea (46%N) were tested in the split-plot design with four replications. The results showed that, the highest straw and grain yield, and its components were resulted from a mixture of irrigated barley under 40% ASMD with ammonium sulfate as a form of N fertilization. Furthermore, it yielded the highest seasonal water use and water productivity results. In addition, the farm economic retune of treatments take the same trend.