While mankind believed that they have reached unprecedented heights in every sphere of Technology and Civilization, the breakout of fatal pandemics in of late has broken that perception and served as a wakeup call. A slew of viruses has immersed in the environment imposing a serious threat to the survival of nearly all human beings on the planet. As the pandemic subsides, WHO declares the monkey box outbreaks as a public health emergency of international concern and lesson from COVID-19 geared up to deal with this outbreak. It is caused by clade IIb strain and the natural reserve virus is unknown whereas small mammals such a squirrels and monkeys are susceptible. This review encompasses compending encapsulation of molecular virology of virus their sign and symptoms, transmission, diagnosis and underlying pathogenesis, focuses on their mechanics. In addition, method for preventing and treating this viral infections. Current epidemiological overview is also taken into consideration.