This study was carried out in Gemmiza Agricultural Research Station, Agricultural Research Center during two successive seasons 2014/2015 and 2015/2016 in order to determine genotypic and phenotypic coefficient variation, heritability and genetic advance for yield and its contributing parameters in three faba bean genotypes (Giza 3, Misr 1 and Giza 843) planted in six different natural infested soil with Orobanche crenata collected from six different farms at Agricultural Research Stations (Shandweel, Mallawy, Sids Giza, Nubaria and Sakha) comparing with soil of farm of Gemmieza Res. Station ( free) as a check in lysometers. The area of Lysometer 1 x 2 m = 2 m2 and 1.5 m height. Determination of the separated seeds of Orobanche was performed visually by microscope. Analysis of variance for studied traits showed significant (P≥ 0.01) differences among the cultivars, soils and interaction between them. The estimated value of heritability in broad sense was found for days to 50% flowering (67.4%), no. of branches/plant (82.1%) , no. of pods/plant (88.1%), no. of seeds/plant (93.0%), seed yield/plant g. (92.7%), date of Orobanche emergence (%97.9), no. of Orobanche spikes/m2 (76.8%) and Orobanche dry weight g/m2 (77.3%). High heritability indicated that selection based on mean would be successful in improving these traits. Expected genetic gains from selecting the top 5% of the characters under study as a percent of the mean revealed 37.4, 57.9, 57.1 and 60.9% for no. of branches / plant, no. of pods/plant, no. of seeds/plant and seed yield/plant g. High heritability estimates along with high genetic advance for seed yield/plant indicated an additive gene action in its inheritance.