The current study was carried out to assess the efficacy of some natural compounds (peppermint oil and camphor oil) and Varroacides (bayvarol, formic acid (65%), Varokiler and varofiga) for controlling Varroa mites in honey bee colonies during winter season in Gharbiya Governorate, Egypt. Results from this study found that, the total numbers of Varroa mites fallen on sticky boards were 2123, 2627, 1888, 2150, 1743, 1269, 1319 and 1208 (Varroa/colony), with an average was 163.30, 202.20, 145.23, 165.38, 134.07, 97.60, 101.46 and 92.9 (Varroa/colony) for honeybee colonies treated with mint oil, camphor oil, varo killer, bayvarol, formic acid, varoviga (with sugar syrup), varoviga (with sugar powder) and untreated check (control), respectively. It also found that, the number of Varroa mites fallen on sticky boards per month was 497.10, 640.70, 459.25, 520.20, 421.45, 304.35, 322.10 and 294.00 (Varroa/colony/month) for aforementioned treatment during the season. From the current study it can summarized that mint oil, camphor oil, and Bayvarol treatments significantly surpassed other treatments in total and average numbers of varroa mites fallen on sticky boards without significant differences between them, followed by formic acid and Varro killer treatment without significant differences between them, meanwhile Varro viga significantly wasn't effect Varroa mites as compared with untreated check (control).