Stem rust caused by Puccinia graminis f. sp. tritici (Pgt), has been considered the most common rust dis-ease of wheat. Twenty Egyptian wheat varieties were screened for resistance to stem rust infection at both seed-ling and adult stages. At the seedling stage, only Misr-3, Misr-4, Gemmeiza-12, and Giza-171 out of twenty wheat varieties had the highest efficacy against the TTTTF and TKTTC races of P. graminis f. sp. tritici. In contrast, Gemmeiza-9, Gemmeiza-11, Sakha-95, Shandweel-1, Shandweel-2, and Nubaria-2 had the highest efficacy against the second race (TKTTC). Moreover, the Sakha-95 variety was moderately resistant to the TTTTF race, while Gemmeiza-10, Sakha-93, Sakha-94, Giza-168, Sids-13, and Sids-14 were moderately re-sistant to the TKTTC race. Contrary, Misr-1, Misr-2, Gemmeiza-9, Gemmeiza-10, Gemmeiza-11, Sakha-93, Sakha-94, Giza-168, Sids-12, Sids-13, Sids-14, Shandweel-1, Shandweel-2, Nubaria-2, and Morocco had the lowest efficacy against TTTTF race; while, Misr-1, Misr-2, Sids-12, and Morocco had the lowest efficacy against the TKTTC race. At the adult stage, field reaction of stem rust on twenty wheat varieties was recorded as disease severity (%), and the area under the disease progress curve (AUDPC) during three growing seasons (2020-2022). Based on the correlation analysis, the significance of the chosen disease parameters, particularly final rust se-verity (FRS%) was validated. FRS% is considered the more suitable indication, rather than the AUDPC for evaluating wheat varieties against stem rust disease.