Increase of modern industries, agricultural activities, and human activities are the main sources of heavy metals (HMs) and other contaminants into ecosystems which might induce threats to non-target organisms and humans.  Therefore, the study conducted the sorption of HMs onto two nanocomposites of cellulose acetate (CA), and polyethylene glycol (PEG) from aqueous solutions. The experiments were conducted to obtain the contact time, dosage of metals and nanomaterials (NMs), and pH effects on removal efficiency. Sorption results were then fitted using Langmuir and Freundlich isotherm models. Dosage effect of HMs: copper (Cu), cadmium (Cd), lead (Pb), and nickel (Ni) at range 0.25-8.0 µg indicated removal % 90.0-99.8% at constant time 1 hr, temperature 25 ^°C, pH 7.0 and nano-dosage (0.05 gram). Nano-dosage effect indicated the removal % over 90.0% at all experiments. Most results were fitted to Langmuir model as favorable pattern for HMs which highlighted their elevated potency to remediate the water from HMs contamination.