A total of 4450 normal lactation records of Egyptian buffaloes kept at Mehalet Mousa Farm, belonging to Animal Production Research Institute (APRI), Agriculture, Research Center, Ministry of Agriculture, Cairo, Egypt, during the period from 1990 to 2022 were used in this study to estimate phenotypic and genetic parameters for productive and reproductive traits. Variables studied were milk yield (MY), days in milk (DM), and days dry (DD), as productive traits and days open (DO), as reproductive trait. Data were analysis by using multi- traits animal model (Boldman et al., 1995). Means of MY, DM, DD, and DO were 1714 kg, 213 d, 217 d and 116 d, respectively. Least squares analysis of variances showed that sires of the cows and cows within sires had a significant effect on MY, DM and DD, while had no significant effects on DO. Year and month of parturition, parity and level of production (three levels of production) had a significant effect on most variables studied. Estimates of partial linear and quadratic regression coefficients of MY and DM on DO were significant (P<0.01), being 6.60±0.27 kg/d, and 0.02±.0.0007kg/d2 for MY and 1.011±0.005d/d, and -0.003±0.0001 d/d2 for DM, respectively. Estimates of linear and quadratic regression coefficients of MY and DM on DD were significant (P < 0.01), being -6.50±0.31 kg/d and 0.04±0.0006kg/d2, for MY and -0.988±0.005 d/d and 0.002±0.0001 d/d2 for DM, respectively. Estimates of direct heritability for MY, DM, DD, and DO were 0.24±0.019, 0.13±0.015, 0.07±0.012, and 0.08±0.014, respectively. Estimates of phenotypic and genetic correlations and breeding values for all variables studied are also calculated.