The present investigation was conducted under normal and salinity conditions during the two rice successive seasons of 2020 and 2021. Three CMS lines of rice, IR69625A, G46A and GAB-A were used as female parents. In addition, four Egyptian tester lines viz., Giza179, PR5, PR6 and GZ9399 were used as testers beside their twelve F1 crosses.  A randomized complete block design with three replications was used and the data were analyzed according to line × tester design. The results indicated highly significant differences among genotypes, parents, crosses and parents vs. crosses under the two environments (normal and salinity conditions).The results showed that dominance genetic variance (σ²D) was greater than additive genetic variance for Plant height, Number of panicles/plant, Spikelet fertility %, 1000-grain weight, Grain yield/plant, sodium content and potassium content under normal and salinity conditions, Panicle weight under salinity condition, indicating that non-additive gene action played an important role in the inheritance of this trait. For heterosis over the mid-parents (H.M.P.%): The most desirable hybrids; For grain yield plant-1, the highly values and highly significant heterosis based on mid-parents for grain yield plant-1 were observed for the crosses GAB-A/PR5, GAB-A/PR6, GAB-A/GZ9399, G46A/GZ9399, G46A/PR6 and G46A/PR6 under both conditions.  The following genotypes could use in breeding program and expected improvement in such traits under normal and saline condition, G46A, PR6, GZ9399, Giza179 and GAB-A as a good donor. G46A/PR6, G46A/PR5, GAB-A/ PR6 and IR69625A/Giza179 could use as good crosses.