The present investigation was carried out at Sakha agricultural research station, Kafr El-Sheikh and clayey saline soil at the experimental farm of El-Sirw Agricultural Research Station, Damietta governorate (31°14′N and 31°48′E) at the northern east of the Delta, Agriculture Research Center, Egypt, during 2021 and 2022 seasons. Four rice varietiesi.e.Giza178, Giza179, GZ9399-4-1-1-3-2-2, and Sakha super 300, as a female lines and IET 1444 , Sal 010, GZ 1368 and IR 45427 as tester were utilized. The parental varieties were crossed by using line & tester's analysis and sixteen crosses were obtained. The F1 and their parents were grown and evaluated under saline soil. The studied characters were No of panicles/plant, panicle length (cm), number of filled grains/panicle, sterility percentage/ panicle (%), panicle weight (gm.), 1000-grain weight (gm.), grain yield/plant (gm/plant) and harvest index (%). The obtained results indicated that, the parents, Giza178, Giza179 and IET 1444 were the best parental for general combining ability for studied traits. Meanwhile, the crosses, Giza179×IR45427, Giza178×IET 1444 and Giza179× Sal 010 were the best performing crosses under saline soil conditions and could be used as the most effective for getting promising lines. From this results could be concluded that, the additive genetic variance play important role in the inheritance for grain yield and harvest index characters, so, pedigree method will be effective to develop new promising lines from these crosses under saline soil condition.