This study aimed to assess the impacts of sweet wormwood (Artemisia annua L.) leaves meal supplementation on oxidative status and immune-response of broilers. A total of 240 one-day-old unsexed (Ross 308 classic FF) broiler chicks were randomly distributed into 4 equal groups (60 chicks into 3 replicates/group). The 1st group (control) was fed a basal diet without any A. annua leaves meal, while A. annua leaves meal was added to the basal diet at levels of 0.3, 0.6, and 0.9 %, respectively at the 2nd, 3ed and 4th groups. At the age of 5 wks, broiler fed a diet supplemented with A. annua leaves meal up to 0.9 % showed a highly significant (P≤ 0.01) improvement in the antioxidant status; this evident through a significant increase in the levels of both TAC and SOD and decreasing the amount of MDA in liver tissue. At the same time, there was a highly significant (P≤0.01) improvement in the immune response of broilers fed dietary A. annua leaves meal up to 0.9 %, this improvement represented by an increase in the levels of serum IgA, IgG and IgM. It could be recommended that, supplementation of Artemisia annua leaves meal in broiler diet at levels up to 0.9% positively affected oxidative status and immune-response during the growing period.