This study aimed to shed more light on the impacts of piperine on growth performance, carcass characteristics and oxidative status of broilers. A total of 300 one-day-old unsexed (Ross 308 classic FF) broiler chicks were randomly distributed into 4 equal groups. The 1st group (control negative) was fed a diet without any supplementation, the second group (control positive) was fed a basal diet supplemented with neomycin at the level of 200 mg/kg of feed, while the third and fourth groups were fed a basal diet supplemented with piperine at the level of 50 and 100 mg/kg diet, respectively. At the age of 5 weeks, the best values of productive performance represented in body weight and weight gain were achieved in groups fed a diet supplemented with 100 mg piperine/kg of diet. Feed consumption and feed conversion ratio of broilers were not affected by piperine supplementation levels up to 100 mg/kg of feed. The relative weights of carcass, dressing, liver, bursa of Fabricius, thymus, and spleen were significantly (P≤0.01) increased by increasing the piperine supplementation level up to 100 mg/kg of feed. Additionally, dietary piperine at the level of 100 mg/kg improved the oxidative status; this is evident through a significant increase in the levels of both TAC and SOD and decreasing the amount of MDA in blood plasma. It could be recommended that, a supplemented diet with piperine up to 100mg/kg improved the productive performance traits, carcass characteristics and oxidative status of broiler.