Salt affected soil is one of the limiting factors of cereal crop production all over the world. There are various ways to improve salt-tolerant of crops. One of these methods is the plant breeders and used spray foliar application of antioxidants and growth regulators. The aim of this work was to study the effect of some antioxidants on mitigating salinity stress and improving plant parameters and production of two wheat (Triticum aestivum L.) cultivars grown under salinity stress in the north Delta of Egypt. In a split–split plot design with three replicates. Two wheat cultivars (cv. Sakha 95 and Misr 3) were used with antioxidants foliar spray treatments: control, silicate potassium (300 mg L-1), ascorbic acid (200 mg L-1) and salicylic acid (200 mg L-1) under two types of soil (normal and saline). The results showed that the foliar spray by ascorbic acid (ASA) with Sakha 95 cultivars significantly surpassed plant height, spike length, number of kernels/spike, 1000-kernel weight, grain and biological yield under normal and saline soils. It can be concluded that using c.v Sakha 95 and a foliar spray by the ASA is most effective ways for increasing wheat productivity under salinity stress condition.