Two field experiments were conducted at the farm of faculty of agriculture Kafr El-Sheikh university during 2019/20 and 2020/21 winter seasons to evaluate the role of spraying proline and Abscisic acid to improve tolerance to drought for the two wheat cultivars (Sids 14 and Giza 171). Split plot design were used for each no.of irrigation in both seasons and combined over no.of irrigation and years, in three replicates. The two wheat cultivars were arranged in the main plots. Whereas, spraying treatments (spraying with proline by 10 (PPM), spraying with abscisic acid by 10 (PPM) and control treatment (spraying with distilled water) were allocated in the subplots, it was sprayed in two stages at 35 and 45 days of sowing, and readings were taken at day 55 and 70 and at harvest from the age of the plant. The results showed a significant increase in the values of the yield and yield components represented in plant height (cm), spike length, grain weight/spike, number of grains/spike, weight of 1000 grains, grain yield ton/ha, biological yield ton/ha, straw yield ton/ha and harvest index % by giving full irrigation to wheat plants followed by moderate drought stress. There were significant differences between the tested cultivars (Sids 14, Giza 171) for these traits. In addition, the effect of treatment with abscisic acid and proline in drought conditions was noted to improve the yield and yield components.