Nigella sativa L. (NS) is a broadly used herb-drug for various diseases and has been used as preservative and food additive. Syner-Tox (ST) also has an effect as a binder to myctoxins. This study was conducted to evaluate the efficacy of mycotxin binder (SynerTox) and NS to ameliorate the effect of aflatoxin on broiler chicks. One hundred and fifty, apparently healthy one day old (Ross 308) broiler chicks were obtained from Assiut for Investment and Development Company Assiut. The chicks were evenly distributed into five groups (30 chicks for each). G1 ration free from aflatoxins without any treatment, G2 administered ration contaminated by aflatoxins (AF is 300 ppb), G3 administered ration contains aflatoxins (300 ppb) plus commercial ST in drinking water, G4 administered ration contains aflatoxins (300 ppb) plus NS (10 gm/kg feed) and G5 administered ration contains aflatoxins (300 ppb) plus ST and NS. Results: (a) For performance, weight of the whole body, liver, heart and bursa showed a decrease in G2 (fed aflatoxin-contaminted diet) in comparison with G1 (which fed diet free from aflatoxin) but the weight of these mentioned organs and whole body in G3, G4 and G5 return normal nearly as in G1. (b) For biochemical parameters, ALT, AST, urea, uric acid and creatinine showed some fluctuation either increase or decrease when compared with G1 and G2 or with each other's. Conclusion: In order to reduce any possible aflatoxin toxicity from contaminated diets, NS and ST can be added as a feed additive to chicken diets.