The current study was conducted to evaluate the potential toxic effects of aflatoxins (AFs) in Moulard ducklings. A total of 20 one-day-old Moulard ducklings were classified into two groups, with 10 ducklings in each group. Ducklings in the control group (G1) were fed on an AFs-free diet. In group 2 (G2), ducklings received a naturally AFs-contaminated feed with 50 ppb total AFs for 25 days. Feed intake, weight gain and feed conversion ratio (FCR), symptoms, postmortem changes, hematological and biochemical changes were investigated. Results showed an increase in feed intake with a bad feed conversion ratio (FCR), liver, kidney and thigh muscle hemorrhage in PM lesions, and a significant decrease in body, liver, and gizzard absolute weight of AFs exposed ducks. Also, there was a significant increase in aspartate aminotransferase (AST) and alanine transaminase (ALT) levels, a significant decrease in urea level, and a non-significant decrease in hematological parameters such as Hb, RBCs, WBCs, and platelets in comparison with the control group.