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346400

MIGHT FENUGREEK SEED EXTRACT BE A PROPHYLACTIC THERAPY FROM OSTEOPOROSIS?

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Last updated: 28 Dec 2024

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Abstract

Osteoporosis is a systemic bone disease characterized by reduced bone mass and the deterioration of bone microarchitecture leading to bone fragility and an increased risk of fractures. Fenugreek regulates osteogenic markers and upregulates osteoblast differentiation by stimulating extracellular calcium concentrations as well as osteoblast differentiation. Experimental studies have shown that it increases osteocalcin and bone morphogenic protein-2 (BMP-2) levels in treated cells. Fenugreek causes DNA damage of osteoclasts. Also, fenugreek steroidal saponins hinder osteoclastogenic bone resorption. Trigonelline, a known constituent of fenugreek seeds, showed significant improvement and prevent the progression of osteoporosis We conclude that fenugreek seed extract might be of benefit for prophylaxis from osteoporosis. However, a well-planned randomized controlled trial is needed to have level I evidence of its efficacy

DOI

10.21608/ejor.2023.346400

Keywords

Osteoporosis, fenugreek, osteoclast, osteoblast, bone resorption

Authors

First Name

Mohamed

Last Name

E Abdel-Wanis

MiddleName

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Affiliation

Orthopedic Department, Ar Rass General Hospital, Kingdom of Saudia Arabia. Orthopedic Department, Sohag Faculty of Medicine, Sohag, Egypt

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Orcid

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First Name

Mansour

Last Name

Mohammed Aldhilan

MiddleName

-

Affiliation

Orthopedic Department, Ar Rass General Hospital, Kingdom of Saudia Arabia

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Volume

4

Article Issue

2

Related Issue

46716

Issue Date

2023-12-01

Receive Date

2023-05-12

Publish Date

2023-12-01

Page Start

41

Page End

44

Print ISSN

2682-4744

Online ISSN

2314-6710

Article File

EJOR_Volume 4_Issue 2_Pages 41-44.pdf

PDF . 199.1kB

Link

https://ejor.journals.ekb.eg/article_346400.html

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https://ejor.journals.ekb.eg/service?article_code=346400

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Review articles: systemic review of different literatures.

Type Code

1,829

Publication Type

Journal

Publication Title

Egyptian Journal of Orthopedic Research

Publication Link

https://ejor.journals.ekb.eg/

MainTitle

MIGHT FENUGREEK SEED EXTRACT BE A PROPHYLACTIC THERAPY FROM OSTEOPOROSIS?

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Article

Created At

28 Dec 2024