Aim: To investigate the use of intramedullary screw for fixation of lateral third clavicle fractures including indications, preoperative planning, operative technique, and complications during the study period. Setting and design: Prospectively we used intramedullary screw for fixation of lateral third clavicle fractures either non-displaced, minimally displaced guided by fluoroscopy. Patients and methods: The study included 20 patients after obtaining informed consent who underwent mid-shaft clavicle fractures using intramedullary screw fixation between February 2020 and January 2022. Statistical analysis used: The software for statistical package for social sciences for Windows 10 was used for all statistical calculations. Each variable was tested for its normal value using the Mann-Whitney Test and exact P values were calculated. Significance was set at the P value of less than 0.05. Results: All cases had “good to excellent" functional results according to the Constant and Murley shoulder score. Conclusion: Our results show that intramedullary screw fixation of lateral third clavicle fractures inserted from the lateral to the medial fragment is a simple, reliable and effective method of treatment with overall satisfactory functional and cosmetic results and low morbidity.