Purpose: To investigate the different etiologies of eye globe atrophy in Upper Egypt. Methods: A retrospective analytical study including 302 eyes of 300 patients with eye globe atrophy. Patients were evaluated in terms of age, gender, laterality, axial length, visual evoked potential (VEP), electroretionogram (ERG) and cause of eye atrophy in addition to the assessment of the condition of their non-atrophic eyes. Results: All patients had total blindness in the atrophic globe with no light perception, a mean intraocular pressure (IOP) of 3.96±0.23 mm Hg, a mean axial length of 15.7±3.45 mm and no response of their VEP and ERG. Ocular trauma was the most common cause of eye globe atrophy (53.3%) followed by postoperative atrophy following intraocular surgeries (28.1%), ocular infections or inflammations (13.9%), congenital causes (3%) and tumors (1.7%). Cataract was the most common ocular disease in their non-atrophic eyes (15.7%) followed by open angle glaucoma (12%). VEP and ERG tests were normal in 87.2% and 90.9% of the non-atrophic eyes, respectively. Conclusion: Ocular trauma is the commonest cause of eye globe atrophy in Upper Egypt and thus more efforts should be made to raise community and social awareness to reduce the incidence of ocular trauma.