Introduction: Duane retraction syndrome is a congenital complex strabismus. It was first described in 1887. It is characterized mainly by limitation of ocular movement, with globe retraction. It may be associated with over shooting of the eye. DRS is one of congenital cranial dysinnervation disorders (CCDD), which are congenital, nonprogressive, sporadic, or familial developmental anomalies of the cranial nerves characterized by abnormal eye, eyelid, and/or facial movements. Aim of the work: to study the surgical outcomes of Duane retraction sundrome (DRS) in Sohag University Hospital. Patients and Methods: A prospective non-randomized interventional clinical study done in Sohag University Hospital. Results: 35 patients had DRS out of 960 strabismus patients, only twenty patients were indicated for surgery. Marked improvement of primary ocular deviation, globe retraction and overshooting was noticed.