Purpose: to investigate if or whether there is a connection between serum lipid levels and primary angle-closure glaucoma. Patients and methods: This study is prospective and non-randomized. There were 400 participants total, and they were split into two groups. The first group included 200 patients of PACG, and the Second group included 200 patients of a healthy control group of the same age and sex. For measuring serum lipids for all cases, 12hrs fasting-blood samples were collected, and the enzymatic method (autoanalyzer) was used to assess it. The lipid profile includes all of the total cholesterol, triglycerides (TGL), high-density lipoproteins (HDL), and low-density lipoproteins (LDL). According to the guidelines of National Cholesterol Education Program: Adult Treatment Panel III (NCEP: ATP III), the reference values for lipids were taken. Hence, according to which Hypercholesterolemia is defined as total cholesterol greater than 200 mg/dl, Hypertriglyceridemia, when triglycerides greater than 150 mg/dl, LDL greater than> 130 mg/dl were considered high, and HDL less than 40 mg/dl will be considered low. Results: there was a statistical significance at (p-value < 0.01) for triglyceride. On the other hand, the control group had higher levels of HDL, LDL, and cholesterol than the PACG group. Statistically, there was a significant difference for both HDL and LDL levels at p-value <0.01. In addition, the serum CHOL, HDL, and triglyceride levels were positively correlated with the IOP levels in the study group, while the serum LDL was negatively correlated. In the control group, all parameters showed a positive correlation with the IOP level. The correlation was statistically significant only for LDL in the study group and HDL in the control group. Conclusion: The serum triglycerides of PACG patients are noticeably greater than those of the control group. Increased serum HDL, triglyceride, and cholesterol levels are significantly linked with PACG.