Artificial Intelligence (AI) Applications help to promote and market tourism and health destinations, Therefore the research aims to clarify the role of these applications in marketing health tourism in Egypt, as well as knowing the most important applications of artificial intelligence in marketing health tourism, which is Virtual Reality technology, Augmented reality technology, GIS technology, Robots, Chatbots. The study population was represented by leaders and experts from the Egyptian Ministry of Tourism and Antiquities. Tourism Promotion Authority, and academics specialized in tourism and tourism marketing. The results of the study showed that virtual reality technology is ranked first in marketing health tourism. Using this technology will enable tourism and health sites to market all their services more interactively. Opinions also agreed that the country's weak technological infrastructure is one of the most important challenges facing these applications for marketing health tourism in Egypt. Opinions also strongly agreed on the lack of interest in training using these smart technologies. The study recommended developing the technological infrastructure to keep pace with smart applications, establishing legislation and laws to regulate work with these applications, integrating AI applications into marketing strategies for health tourism destinations.