Icerya seychellarum (Westwood) (Homoptera: Monophelibidae) is the most important mealybug species in Egypt which attacking guava orchards. The purpose of this study was to observe the fluctuations in population of this insect pest in guava orchards throughout two seasons of 2020/ 2021 and 2021/ 2022 in  Rashed region, El-Behara  governorate. The obtained results indicated that, I. seychellarum had 2-3 peaks of population density during the first and second years of the study. There was a good synchronization between nymphal population of I. seychellarum and populations of the two predators Rodalia cardinalis (Mulsant) (r= 0.69 and0.78) and Chrysoperla carnea (Stephens) (r = 0.63 and 0.61) during the previous period. The impact of weather factors (temperature and relative humidity) on population of  I. seychellarum and the associated predators (R. cardinalis and C. carnea) were examined.