This study was carried out during 2021 and 2022 to investigate the role of spraying tryptophan, biozyme and fulvic acid on Le Conte pear cv. grown at a private orchard in Borg El- Arab, Alexandria, Egypt. The experiment design was a Randomized Complete Block Design (RCBD). Ten treatments with four replicates were applied three times; start of growing season, full bloom and one month after fruit set, the treatments were; control, tryptophan at 50, 100 and 150 ppm, biozyme at 2, 4 and 6 ppm and fulvic acid at 500, 1000 and 1500 ppm. The results showed that all treatments enhanced the shoot length and thickness, leaf area and total chlorophyll compared to the control, the highest value of shoot length was obtained by 1500 ppm fulvic acid in 2021 and 6 ppm biozyme in 2022, In the meantime, 1500 ppm fulvic acid caused significant increment, in shoot thickness, leaf area and total chlorophyll, fruit set (%), the number of fruits per tree, yield (kg/ tree) and the least fruit drop % in 2021 and 2022. All treatments enhanced the fruit physical and chemical properties and fulvic acid at 1500 ppm caused remarkable increment in fruit weight and length in the second season and fruit diameter in both seasons. Tryptophan at 150 ppm had the highest percentages of total soluble solids (TSS), total sugars and reducing sugars in the two seasons, while it caused the highest value of TSS/ acid  in 2022 and non- reducing sugars % in the first season. In the meantime, fulvic acid at 1500 ppm significantly increased the TSS/ Acid in 2021 and 2022 seasons, in one side and reducing sugars % in the first season, on the other side. In contrast, all treatments reduced acidity (%) and ascorbic acid mg/100ml compared with control. The level of minerals improved by all treatments in comparison with the control, 6 ppm biozyme caused the highest value in phosphorus and potassium % and copper ppm in 2020 and 2021. 1500 ppm fulvic acid estimated the highest value in nitrogen (%), manganese and copper (ppm), whereas, the increase in leaf zinc ppm was obtained by 150 ppm tryptophan in the two seasons.