The spider mite and pink bollworm are considered two of the most important pests attacking cotton plants and causing serious damage to leaves, flowers and bolls. Thus, the experiments were carried out at Sakha Agric. Research Station, Kafr El-Sheikh governorate during the seasons 2020 and 2021. However, the field experiments used compounds were one insecticide, beta cyfluthrin; three biocides,  emamectin benzoate, Bacillus thuringiensis and Beauveria bassiana and one plant oil, jasmine oil which were tested against the two spotted spider mite, Tetranychus urticae Koch (Acari: Tetranychidae) and Pectinophora gossypiella (Saunders) (Lep: Noctuidae) using standardized method for assay. The highest effective compounds on T. urticae and P. gossypiella were emamectin benzoate (95.59 and 96.65 % reduction during the two seasons, respectively on T. urticae and 70.45 and 71.60 % reduction on P. gossypiella during the 1^st and 2^nd seasons, respectively). Beta cyfluthrin and B. bassiana had a moderate activity on the two pests followed by B. thuringiensis. Jasmine oil had the least activity on the treated T. urticae and P. gossypiella (33.89 and 33.79 % reduction during the first season, respectively) and there were not significant differences between each compound and others during the two seasons. In laboratory trails, beta cyfluthrin was the most effective with LC₅₀ 2.61 and 1.45 mg / L 0n both adult and eggs of T. urticae, respectively followed by emamectin benzoate.While B. bassiana was of a moderate toxic with LC₅₀ 63300 and 44200 using dipping method. Beta cyfluthrin was the most toxic to P. gossypiella with LC₅₀ 2.99 mg / L. While B. bassiana was the low effective on P. gossypiella with LC₅₀ 64100 mg / L using the artificial diet treatment method. The obtained data indicated that     biocides caused significant against the two pests and could be used as alternatives to pesticides in IPM.