Sugar beet crop has recently become the first source of sugar production in Egypt, followed by sugar cane. The tortoise beetle, Cassida vittata Vill is an important insect pest infesting sugar beet plants, and causing considerable yield losses. The current study was carried out at , Kafr El-Sheikh region during 2020/ 2021 and 2021/ 2022 seasons to evaluate the efficacy of some insecticides against C. vittata and their side effects on some arthropod predators. Carbosulfan was the most potent insecticide against the beetle one day after treatment; 90.68 and 93.35% larval insect reduction in the first and second seasons, respectively. Ten days after treatment, these reductions reached 98.55 and 99.78% in the first and second seasons, respectively. acetamiprid+biferthrin reduced C. vittata larval population by 98.55 and 98.87%, while the bioinsecticide, spinetoram reduced the insect population by 86.62 and 87.32% ten days after treatments in 2020/ 2021 and 2021/ 2022 seasons, respectively. The evaluated insecticides induced high harmful side effects on some predators occurring in sugar beet fields. Overall reduction in Coccinella undecimpunctata due to acetamiprid+biferthrin was 99.13-99.24%, due to and was 97.15-99.19%. The corresponding values of the two insecticides on Paederus alfierii were 84.65-93.26 and 70.59-93.44%.The spider populations were reduced by 83.15-92.13 and 86.75 – 89.15% for the first and second insecticides, respectively. However, the bioinsecticide, spinetoram was the safest on predators, which induced 28.03 - 28.83, 41.79 - 45.04 and 32.59 – 36.82% in the populations of C. undecimpunctata, P. alfierii and spiders respectively.