ABSTRACT: The objective of this work was to investigate the effect of molybdenum, phosphorus and sulfur on the growth and elements content in wheat (Triticum aestivum L) grown under saline soil conditions. To achieve this work, a field experiment was conducted at the experimental research station of Faculty of Agriculture, Saba Basha, Alexandria University. Four rates of molybdenum (0, 50, 100, and 200 g Mo /fed.), four phosphorus rates (0, 7.5, 15 and 22.5 kg P/fed.) and four sulphur rates (0, 50, 100 and 200 kg S/fed) were applied in a split split plot design with three replicates. Molybdenum, phosphorus and sulphur significantly improved grain yield of wheat. The highest grain yield (1.91 ton/ fed) was obtained with application of 200 kg S/ fed, 22.5 kg P/fed and 100 g Mo/fed rates. The contents of N, P, K, and S in wheat leaves were also increased due to phosphorus and sulphur application rates, but Mo concentration in the leaves was depressed due to sulphur application and increased with phosphorus and molybdenum applications.