Nowadays, the issue of counterfeiting in the pharmaceutical industry is one of the main challenges facing many countries. maybe due to the lack of effective methods of tracking the product through the different stages of the supply chain and the lack of concurrent observations between all parties involved in the system about the current status of the product.  The research purposes a framework that integrates the blockchain technology with Internet of Things (IoT) based technology.  Pharmacy supply chain management system can provide greater security. We look at peer-reviewed blockchain technologies against two criteria for supply chains:  on-chain storage and off-chain storage. Therefore, we used the Inter Planetary File System  (IPFS) to achieve tamper-proof storage to avoid unauthorized modifications. Thus, we have achieved a great degree of transparency and trust in the supply chain. Improving the methods of controlling the storage, shipping, and distribution, through the constant storage of product status changes that are shared across all parties enables verification of product authenticity across various parties in the supply chain to leverage the blockchain.